5-MTHF Plus B12 features Quatrefolic and methylcobalamin in great-tasting, quick-dissolve tablet form. Quatrefolic is the glucosamine salt of 5-MTHF—the most biologically active form of folate that increases plasma folate more effectively than folic acid. This supplements supports methylation, nervous system health, normal cellular proliferation (including red blood cells), healthy serum folate levels and a healthy pregnancy outcome.