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Mn-Zyme supplies a source of supplemental manganese, an essential trace mineral. Manganese is a cofactor for the synthesis of glycosaminoglycans (chondroitin sulfate), and as such is an important component in musculoskeletal health. Additionally, according to Natural Standard, "Mn is a cofactor for some enzymes, aids in the synthesis of fatty acids and cholesterol, facilitates protein and carbohydrate metabolism, and may also participate in maintaining reproductive health."